It's easier said than done, but if the Arizona Cardinals can slow down the San Francisco 49ers' running game, they have a chance in Week 5 tilt.

The Arizona Cardinals and San Francisco 49ers have unveiled their first injury report of Week 5, and it's unfortunately littered with big names on both sides: DNP - Isaiah Adams (thumb), Kelvin Beachum (hamstring),

The San Francisco 49ers will be without two All-Pros for their opening practice ahead of Sundays' Week 5 matchup with the Arizona Cardinals. Kyle Shanahan confirmed that tight end George Kittle (ribs) and Fred Warner (ankle) would both miss Wednesday's practice.

The San Francisco 49ers look for their first back-to-back wins of the season when they host the division rival Arizona Cardinals.

The Cardinals are coming off their worst game of the season. These stats from the Niners’ game in Week 4 are not comforting.

The Week 5 NFC West matchup between the Cards and 49ers features two teams that are better than their records might indicate, but both Chris Simms and Mike Florio is riding San Francisco at home as a touchdown favorite.