49ers head coach Kyle Shanahan spoke highly of Murray and considers him one of the most dangerous players in the league especially when things go off-schedule on the field. He noted something many have observed about Murray this year. “He just looks so much more comfortable,” Shanahan told reporters on Wednesday.

In his best game of the season -- Week 2 versus the Los Angeles Rams -- Kyler Murray finished with 28.5 fantasy points. His stat line: 17-of-21 (81%), 266 yards, 3 TDs, 0 INTs; 5 carries, 59 yards.

San Francisco 49ers coach Kyle Shanahan knows he will have his hands full preparing for Arizona Cardinals quarterback Kyler Murray this week.

When the San Francisco 49ers (2-2) and Arizona Cardinals (1-3) play on Oct. 6 at Levi's Stadium, Brock Purdy and Kyler Murray will be under center for their respective offenses. Which QB has the advantage in this bout? Find out below.

Kyler Murray is having the best season of his career. He's one of the most dangerous players in the NFL. And he'll face the 49ers at Levi's Stadium on Sunday.

Washington Commanders Pro Bowl tight end Zach Ertz has sent his team a warning about Arizona Cardinals QB Kyler Murray ahead of Week 4.

After the challenge of trying to bring down New England Patriots quarterback Jacoby Brissett in Week 4, Nick Bosa and the 49ers' defensive line have a new test on deck this Sunday in Arizona Cardinals signal-caller Kyler Murray.

Arizona Cardinals QB Kyler Murray knows the team's 1-3 start isn't acceptable. Losses to teams such as the Buffalo Bills and Detroit Lions were close, though their Week 4 humbling to the Washington Commanders in 42-14 fashion left a different taste in Murray's mouth.

Arizona Cardinals QB Kyler Murray previewed the team's Week 5 matchup against the San Francisco 49ers with LB Fred Warner highlighted as a player to watch.