The Indianapolis Colts will be watching the progress of their quarterback and running back all heading into a Week 5 game in Jacksonville.

Find out who will play and who is out in today's injury report for the Jacksonville Jaguars vs. Indianapolis Colts Week 5 game on Sunday, October 6, 2024.

Jacksonville Jaguars safety Andre Cisco spoke to the media on Wednesday about the Week 5 matchup with the Indianapolis Colts.To see Cisco' comments, view above.Jaguars head coach Doug Pederson also spoke on Monday.

Currently, as of Wednesday morning, BetMGM has the Colts as the early favorites in this matchup, favored by three points. The over/under is set at 46 points and the Colts’ money line is at +125.

Indianapolis Colts quarterback Anthony Richardson "hopes to play" in Sunday's road game against the Jacksonville Jaguars, per ESPN's Jeremy Fowler.

IndyStar insiders Joel A. Erickson and Nate Atkins break down the Colts’ upcoming trip to their own (and Joel’s) personal house of horrors, the city of Jacksonville, and all the uncertainty Indianapolis is facing due to a rash of injuries.

Jacksonville is 4-2 in games Lawrence has played against the Colts. He has completed 70.7% of his passes vs. Indianapolis for 1,207 yards, 9 touchdowns and 2 interceptions. The Co

Colts at Jaguars Week 5 Preview & Picks

Here's everything you need to know when the Indianapolis Colts play the Jacksonville Jaguars Week 5 of the 2024 NFL season.